DataSheet1_A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy.docx (1.93 MB)
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posted on 2021-06-14, 04:26 authored by Xiang Xia, Ran Wang, Yingqi Hu, WeiJian Liu, Ting Liu, Wen Sun, Jiangli Fan, Xiaojun PengLipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet–targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging–guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet–location PDT.
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