IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells
Previous studies infecting global IL-4Rα−/−, IL-4−/−, and IL-13−/−mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4Rα deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donovani infection. Here we expand on these findings and show that CD4+ T cell-(Lckcre), as well as pan T cell-(iLckcre) specific IL-4Rα deficient mice, on a BALB/c background, unlike global IL-4Rα deficient mice, are also not adversely affected in terms of resistance to primary infection with L. donovani. Our analysis suggested only a transient and tissue specific impact on disease course due to lack of IL-4Rα on T cells, limited to a reduced hepatic parasite burden at day 30 post-infection. Consequently, the protective role(s) demonstrated for IL-4 and IL-13 during L. donovani infection are mediated by IL-4Rα-responsive cell(s) other than macrophages, neutrophils and T cells.
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REFERENCES
- https://doi.org//10.1017/S0031182017002116
- https://doi.org//10.1080/21645515.2018.1430542
- https://doi.org//10.1016/S1473-3099(16)00078-5
- https://doi.org//10.3389/fimmu.2019.00598
- https://doi.org//10.1084/jem.185.5.867
- https://doi.org//10.1084/jem.189.4.741
- https://doi.org//10.1016/j.jtbi.2016.10.004
- https://doi.org//10.1172/JCI116372
- https://doi.org//10.1002/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T
- https://doi.org//10.1128/IAI.71.8.4804-4807.2003
- https://doi.org//10.1093/infdis/jir080
- https://doi.org//10.1086/315890
- https://doi.org//10.1002/1521-4141(200010)30:10<2935::AID-IMMU2935>3.0.CO;2-Q
- https://doi.org//10.1111/pim.12535
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AUTHORS (7)
CATEGORIES
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity