Video_6_Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration.avi (1.63 MB)
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Video_6_Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration.avi

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posted on 24.02.2022, 04:55 authored by Zheming Liu, Jing Wang, Fuben Liao, Qibin Song, Yi Yao

Platelets are small anucleate cells that circulate in the blood and form thrombi. Tumor-educated platelets are the platelets derived from cancer patients. Although many have reported that tumor-educated platelets are associated with cancer-associated thrombosis, their function in this process is poorly understood. Here we first collect the clinical data from 100 different cancer patients, showing that cancer patients are in a hypercoagulable state. Our experiment shows that tumor-educated platelets from melanoma-burdened mouse models can migrate faster and longer, forming more clots (thrombus). However, the plasma from tumor mice can inhibit platelet migration. The RNA sequence profile of tumor-educated platelets shows that many genes associated with cell migration and cell skeleton expressed significantly higher. Our research offers a new insight into the tumor-educated platelets to better understand the thrombus formation.

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