Image_7_Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization.TIF (3.15 MB)
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posted on 02.06.2021, 05:08 by Zhen Xiong, Qianqian Wang, Wanhong Li, Lijuan Huang, Jianing Zhang, Juanhua Zhu, Bingbing Xie, Shasha Wang, Haiqing Kuang, Xianchai Lin, Chunsik Lee, Anil Kumar, Xuri Li

Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.

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