Image_4_TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.tif (10.53 MB)

Image_4_TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.tif

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posted on 12.05.2020, 16:43 by Nathalie Krauth, Valentina Khalil, Meet Jariwala, Noemie Mermet-Joret, Anne-Katrine Vestergaard, Marco Capogna, Sadegh Nabavi

A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.

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