Image_3_TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.TIF (2.28 MB)

Image_3_TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.TIF

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posted on 12.05.2020 by Nathalie Krauth, Valentina Khalil, Meet Jariwala, Noemie Mermet-Joret, Anne-Katrine Vestergaard, Marco Capogna, Sadegh Nabavi

A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.

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