Image_3_Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory in Drosophila.TIF (3.05 MB)

Image_3_Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory in Drosophila.TIF

Download (3.05 MB)
figure
posted on 03.07.2018, 09:58 by Alja Lüdke, Georg Raiser, Johannes Nehrkorn, Andreas V. M. Herz, C. Giovanni Galizia, Paul Szyszka

Animals can form associations between temporally separated stimuli. To do so, the nervous system has to retain a neural representation of the first stimulus until the second stimulus appears. The neural substrate of such sensory stimulus memories is unknown. Here, we search for a sensory odor memory in the insect olfactory system and characterize odorant-evoked Ca2+ activity at three consecutive layers of the olfactory system in Drosophila: in olfactory receptor neurons (ORNs) and projection neurons (PNs) in the antennal lobe, and in Kenyon cells (KCs) in the mushroom body. We show that the post-stimulus responses in ORN axons, PN dendrites, PN somata, and KC dendrites are odor-specific, but they are not predictive of the chemical identity of past olfactory stimuli. However, the post-stimulus responses in KC somata carry information about the identity of previous olfactory stimuli. These findings show that the Ca2+ dynamics in KC somata could encode a sensory memory of odorant identity and thus might serve as a basis for associations between temporally separated stimuli.

History

References

Licence

Exports