Frontiers
Browse
Image_2_The association between oral and gut microbiota in male patients with alcohol dependence.TIF (3.23 MB)

Image_2_The association between oral and gut microbiota in male patients with alcohol dependence.TIF

Download (3.23 MB)
figure
posted on 2023-07-28, 04:05 authored by Lingming Hu, Zhaojun Ni, Kangqing Zhao, Xiangxue Li, Xuejiao Gao, Yulin Kang, Zhoulong Yu, Ying Qin, Jingwen Zhao, Wenjuan Peng, Lin Lu, Hongqiang Sun
Introduction

The relationship between oral and gut microbiota in alcohol dependence (AD) is not well understood, particularly the effects of oral microbiota on the intestinal microbiota. The current study aimed to explore the association between oral and gut microbiota in AD to clarify whether oral microbiota could ectopically colonize into the gut.

Methods

16S rRNA sequence libraries were used to compare oral and gut microbial profiles in persons with AD and healthy controls (HC). Source Tracker and NetShift were used to identify bacteria responsible for ectopic colonization and indicate the driver function of ectopic colonization bacteria.

Results

The α-diversity of oral microbiota and intestinal microbiota was significantly decreased in persons with AD (all p < 0.05). Principal coordinate analysis indicated greater similarity between oral and gut microbiota in persons with AD than that in HC, and oral-gut overlaps in microbiota were found for 9 genera in persons with AD relative to only 3 genera in HC. The contribution ratio of oral microbiota to intestinal microbiota composition in AD is 5.26% based on Source Tracker,and the AD with ectopic colonization showed the daily maximum standard drinks, red blood cell counts, hemoglobin content, and PACS scores decreasing (all p < 0.05).

Discussion

Results highlight the connection between oral-gut microbiota in AD and suggest novel potential mechanistic possibilities.

History

Usage metrics

    Frontiers in Microbiology

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC