Image_2_The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation.JPEG (304.95 kB)
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Image_2_The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation.JPEG

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posted on 20.11.2019, 04:25 authored by Timothy J. Thauland, Humza A. Khan, Manish J. Butte

Alpha-adducin (Add1) is a critical component of the actin-spectrin network in erythrocytes, acting to cap the fast-growing, barbed ends of actin filaments, and recruiting spectrin to these junctions. Add1 is highly expressed in T cells, but its role in T-cell activation has not been examined. Using a conditional knockout model, we show that Add1 is necessary for complete activation of CD4+ T cells in response to low levels of antigen but is dispensable for CD8+ T cell activation and response to infection. Surprisingly, costimulatory signals through CD28 were completely abrogated in the absence of Add1. This study is the first to examine the role of actin-capping in T cells, and it reveals a previously unappreciated role for the actin cytoskeleton in regulating costimulation.

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