Image_2_Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer.tif (566.27 kB)
Download file

Image_2_Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer.tif

Download (566.27 kB)
figure
posted on 27.10.2021, 04:34 authored by Qin Dang, Zaoqu Liu, Shengyun Hu, Zhuang Chen, Lingfang Meng, Junhong Hu, Guixian Wang, Weitang Yuan, Xinwei Han, Lifeng Li, Zhenqiang Sun

Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy.

History

References