Image_2_Dependence on Dectin-1 Varies With Multiple Candida Species.JPEG
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.
History
References
- https://doi.org//10.1016/j.idc.2010.11.003
- https://doi.org//10.1007/s15010-002-2131-0
- https://doi.org//10.1038/nmicrobiol.2016.238
- https://doi.org//10.1038/ni.2987
- https://doi.org//10.1128/iai.69.8.5046-5055.2001
- https://doi.org//10.1126/scitranslmed.3004404
- https://doi.org//10.1080/21505594.2017.1346756
- https://doi.org//10.1371/journal.ppat.1006290
- https://doi.org//10.1139/cjm-2017-0559
- https://doi.org//10.3389/fmicb.2015.01527
- https://doi.org//10.1128/cmr.12.1.80
- https://doi.org//10.1038/nrmicro2711
- https://doi.org//10.1371/journal.ppat.1003276
- https://doi.org//10.1086/591861
- https://doi.org//10.1128/IAI.01189-13
- https://doi.org//10.1089/jir.2015.0040
- https://doi.org//10.11604/pamj.2014.19.398.4960
- https://doi.org//10.1038/ni1460
- https://doi.org//10.1080/13693780903164566
- https://doi.org//10.1016/s0092-8674(00)80358-x
- https://doi.org//10.1128/mBio.02120-18
- https://doi.org//10.1371/journal.ppat.1003315
- https://doi.org//10.1172/jci27114
- https://doi.org//10.4049/jimmunol.1501204
- https://doi.org//10.1016/j.semcdb.2018.03.003
- https://doi.org//10.3389/fmicb.2016.00306
- https://doi.org//10.1084/jem.20082818
- https://doi.org//10.1038/ni1425
- https://doi.org//10.1016/j.immuni.2010.05.001
- https://doi.org//10.12688/f1000research.13020.1
- https://doi.org//10.3389/fcimb.2016.00186
- https://doi.org//10.1111/j.1574-6976.2011.00278.x
- https://doi.org//10.1038/ni1408
- https://doi.org//10.1093/infdis/jit188
- https://doi.org//10.1128/CMR.00013-08