Image_1_Association Between Low-Density Lipoprotein Cholesterol and Platelet Distribution Width in Acute Ischemic Stroke.tif (423.33 kB)
Download file

Image_1_Association Between Low-Density Lipoprotein Cholesterol and Platelet Distribution Width in Acute Ischemic Stroke.tif

Download (423.33 kB)
figure
posted on 05.03.2021, 05:10 authored by Jian Yuan, Jian Cai, Pei Zhao, Nan Zhao, Rong-Hua Hong, Jie Ding, Jin Yang, Qing-Lei Fan, Jian Zhu, Xia-Jun Zhou, Ze-Zhi Li, De-Sheng Zhu, Yang-Tai Guan

Objective: Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for ischemic stroke; however, whether LDL-C affects the platelet deformation function in the peripheral blood circulation in patients with acute ischemic stroke (AIS) is unknown. The present study aimed to investigate the relationship between LDL-C and platelet distribution width (PDW) in AIS patients.

Methods: We conducted a cross-sectional hospitalized-based study of consecutive 438 patients with AIS within 24 h. Blood samples were collected upon admission and prior to drug administration, and LDL-C and PDW (a parameter that reflects the heterogeneity of platelet volume) were assessed. The relationship between LDL-C and PDW were analyzed by linear curve fitting analyses. Crude and adjusted beta coefficients of LDL-C for PDW with 95% confidence intervals were analyzed using multivariate-adjusted linear regression models.

Results: The PDW was significantly higher in the high LDL-C group compared with those in the normal LDL-C group (16.28 ± 0.37 fl vs. 16.08 ± 0.37 fl, p < 0.001). Adjusted smoothed plots suggested that there are linear relationships between LDL-C and PDW, and the Pearson's correlation coefficient (95%) was 0.387 (0.304–0.464, p < 0.001). The beta coefficients (95% CI) between LDL-C and PDW were 0.15 (0.12–0.18, p < 0.001) and 0.14 (0.11–0.18, p < 0.001), respectively, in AIS patients before and after adjusting for potential confounders.

Conclusion: Our study suggested that the elevated LDL-C level was related to increased PDW among AIS patients.

History

References