Image_1_Allograft or Recipient ST2 Deficiency Oppositely Affected Cardiac Allograft Vasculopathy via Differentially Altering Immune Cells Infiltration.tif
The role of IL-33/ST2 signaling in cardiac allograft vasculopathy (CAV) is not fully addressed. Here, we investigated the role of IL-33/ST2 signaling in allograft or recipient in CAV respectively using MHC-mismatch murine chronic cardiac allograft rejection model. We found that recipients ST2 deficiency significantly exacerbated allograft vascular occlusion and fibrosis, accompanied by increased F4/80+ macrophages and CD3+ T cells infiltration in allografts. In contrast, allografts ST2 deficiency resulted in decreased infiltration of F4/80+ macrophages, CD3+ T cells and CD20+ B cells and thus alleviated vascular occlusion and fibrosis of allografts. These findings indicated that allografts or recipients ST2 deficiency oppositely affected cardiac allograft vasculopathy/fibrosis via differentially altering immune cells infiltration, which suggest that interrupting IL-33/ST2 signaling locally or systematically after heart transplantation leads different outcome.
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References
- https://doi.org//10.1016/j.jacc.2019.05.028
- https://doi.org//10.1016/j.healun.2011.08.017
- https://doi.org//10.4070/kcj.2018.0189
- https://doi.org//10.26355/eurrev_201901_16777
- https://doi.org//10.1016/j.healun.2020.08.003
- https://doi.org//10.1002/path.3968
- https://doi.org//10.1684/ecn.2019.0429
- https://doi.org//10.1097/TP.0b013e3181d720af
- https://doi.org//10.1111/imr.12619
- https://doi.org//10.1111/j.1432-2277.2011.01306.x
- https://doi.org//10.1172/JCI133008
- https://doi.org//10.1016/j.yjmcc.2019.01.018
- https://doi.org//10.1111/ajt.12781
- https://doi.org//10.1038/nprot.2007.48
- https://doi.org//10.1038/labinvest.2016.54
- https://doi.org//10.1371/journal.pone.0225624
- https://doi.org//10.1111/ctr.13794
- https://doi.org//10.1093/cvr/cvy166
- https://doi.org//10.1186/s12974-018-1169-6
- https://doi.org//10.1152/ajpregu.00435.2016
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Categories
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity