table_2_Expression and Function of Tetraspanins and Their Interacting Partners in B Cells.XLSX (12.86 kB)
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table_2_Expression and Function of Tetraspanins and Their Interacting Partners in B Cells.XLSX

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posted on 18.07.2018, 04:04 by Fagui Zou, Xu Wang, Xinxin Han, Gerson Rothschild, Song Guo Zheng, Uttiya Basu, Jianbo Sun

Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell–cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

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