Table_4_Molecular Characterization and Clinical Relevance of Lysine Acetylation Regulators in Urological Cancers.xlsx (11.2 kB)
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Table_4_Molecular Characterization and Clinical Relevance of Lysine Acetylation Regulators in Urological Cancers.xlsx

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posted on 31.05.2021, 14:52 authored by Jian Zhang, Chunning Zhang, Huali Jiang, Hualong Jiang, Yawei Yuan
Background

Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracellular responses. However, knowledge regarding the status of lysine regulators in urological cancers is still unknown.

Methods

We first systematically analyzed the genetic and expression alterations of 31 lysine acetylation regulators in urological cancers. The correlation between lysine acetylation regulators and activation of cancer pathways was explored. The clinical relevance of lysine acetylation regulators was further analyzed.

Results

We identified that there are widespread genetic alterations of lysine acetylation regulators, and that their expression levels are significantly associated with the activity of cancer hallmark-related pathways. Moreover, lysine acetylation regulators were found to be potentially useful for prognostic stratification. HDAC11 may act as a potential oncogene in cell cycle and oxidative phosphorylation of urological cancers.

Conclusion

Lysine acetylation regulators are involved in tumorigenesis and progression. Our results provide a valuable resource that will guide both mechanistic and therapeutic analyses of the role of lysine acetylation regulators in urological cancers.

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