Table_2_Single Hormone Receptor-Positive Metaplastic Breast Cancer: Similar Outcome as Triple-Negative Subtype.docx
Metaplastic breast cancer (MBC) is a rare and aggressive subtype of the breast. To understand the characteristics and prognosis of single hormone receptor-positive (HR+) MBC (estrogen receptor-positive [ER+]/progesterone receptor-negative [PR-] and ER-/PR+), we compared these tumors to double HR+ tumors as well as HR- tumors.
Patients and MethodsThe Surveillance, Epidemiology, and End Results database was used to analyze MBC between 1975 and 2016. The effect of HR status was evaluated using a multivariate Cox regression model.
ResultsWe included 3369 patients with a median follow-up time of 42 months (range 0-322 months). In this study, 280 (8.3%) cases were double HR+ tumors, 2597 (77.1%) were double HR- tumors, and 492 (14.6%) cases were single HR+ tumors, of which 159 (4.7%) cases were ER-/PR+ tumors and 333 (9.9%) were ER+/PR- tumors. On multivariate Cox analysis, the prognosis was related to age, race/ethnicity, tumor grade, TNM stage, and surgery. HR status remained no impact on breast cancer-specific survival (BCSS). In the Kaplan-Meier curve, HR status was not associated with better BCSS or overall survival (OS). In patients without HER2 overexpression, the BCSS and OS of ER+/PR- and ER-/PR+ tumors were not significantly different from that of ER-/PR- and ER+/PR+ tumors. The difference remains no significant in patients with HER2 overexpression.
ConclusionsIn comparison with both ER-/PR- and ER+/PR+ tumors, we have identified clinically and biologically distinct features of single HR+ tumors. In patients with or without HER2 overexpression, the prognosis of single HR+ tumors was similar to ER-/PR- and ER+/PR+ tumors.
History
References
- https://doi.org//10.1097/00000478-198712000-00002
- https://doi.org//10.1016/0046-8177(89)90065-8
- https://doi.org//10.1016/0046-8177(89)90149-4
- https://doi.org//10.1002/1097-0142(19891001)64:7<1490::aid-cncr2820640722>3.0.co;2-l
- https://doi.org//10.1002/1097-0142(19900115)65:2<272::aid-cncr2820650215>3.0.co;2-6
- https://doi.org//10.1016/0046-8177(90)90151-t
- https://doi.org//10.1136/jclinpath-2011-200586
- https://doi.org//10.6004/jnccn
- https://doi.org//10.1245/s10434-006-9124-7
- https://doi.org//10.1007/s10549-010-0780-8
- https://doi.org//10.1093/jjco/hyp139
- https://doi.org//10.1007/s10549-006-9301-1
- https://doi.org//10.1245/s10434-014-3890-4
- https://doi.org//10.1007/s10549-011-1359-8
- https://doi.org//10.1093/annonc/mdl006
- https://doi.org//10.1016/j.clbc.2016.06.002
- https://doi.org//10.1016/j.clbc.2016.07.004
- https://doi.org//10.1245/s10434-014-3782-7
- https://doi.org//10.1136/jclinpath-2016-203847
- https://doi.org//10.1200/jco.2003.09.099
- https://doi.org//10.1007/s10549-013-2763-z
- https://doi.org//10.1186/s12885-015-1121-4
- https://doi.org//10.1007/s10549-008-0197-9
- https://doi.org//10.1007/s10549-018-5005-6
- https://doi.org//10.1007/s00795-007-0379-2
- https://doi.org//10.1111/j.1365-2559.2006.02467.x
- https://doi.org//10.1136/jcp.2008.055475
- https://doi.org//10.1007/s10549-004-7260-y
- https://doi.org//10.1136/jcp.2005.030536
- https://doi.org//10.1016/j.ijrobp.2005.08.024
- https://doi.org//10.1016/j.clbc.2014.10.002
- https://doi.org//10.1245/s10434-010-1198-6
- https://doi.org//10.1186/1477-7819-11-129
CC BY 4.0