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Table_2_NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma.XLS (138.52 kB)

Table_2_NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma.XLS

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posted on 06.12.2021, 04:33 authored by Rongqiang Liu, Rongqi Li, Haoyuan Yu, Jianrong Liu, Shiyang Zheng, Yang Li, Linsen Ye

Background: The potential role of Neurotrophic factor-3(NTF3) in liver cancer is unknown. Therefore, we aimed to explore the clinical value of NTF3 in hepatocellular carcinoma (HCC).

Methods: We used a variety of databases to analyze the expression, relationship with prognosis and immune significance of NTF3 in liver cancer through bioinformatics.

Results: NTF3 was low expressed in HCC and was an independent prognostic factor in patients with HCC. CIBERSORT analysis indicated that NTF3 expression was positively correlated with CD4+ cells, mast cells, NK cells, macrophages and B cells in the tumor microenvironment. Furthermore, we found that NTF3 expression was negatively correlated with the immune checkpoints PD-L1, TIGIT and TIM-3. Functional network analysis revealed that NTF3 regulates HCC progression through a variety of cancer-related kinases, transcription factors and signaling pathways.

Conclusions: We demonstrate that NTF3 correlates with prognosis and immune infiltration in HCC.

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