Table_2_Chronic Hepatitis Virus Infection Are Associated With High Risk of Gastric Cancer: A Systematic Review and Cumulative Analysis.doc
Mounting studies demonstrated both chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infection might be associated not only with an increased risk of hepatocellular carcinoma but also extrahepatic malignancies, i.e., gastric cancer (GC). However, a quantitative result addressing the association between HBV/HCV infection and GC development is scarce. A systematic search to identify the eligible studies was performed in four databases, including MEDLINE, EMBASE, Cochrane Library, and the PsychINFO. The relationship between HBV/HCV infection and the risk of GC was quantified by calculating the hazard ratio (HR) with a 95% confidence interval (CI). More methodologies of this study were available in the PROSPERO (ID: CRD42021243719). Thirteen included studies involving 7,027,546 individuals (mean age, 42.6-71.9 years) were enrolled in the pooled analyses. Two articles provided the clinical data of both HBV and HCV infections. The proportion of high methodological quality studies was 76.9% (10/13). Synthetic results from 10 eligible studies of HBV showed that HBV infection was associated with a significantly higher risk of GC when compared with the healthy controls without HBV infection (pooled HR, 1.26; 95% CI, 1.08–1.47; P = 0.003; heterogeneity, I2 = 89.3%; P< 0.001). In line with this finding, the combined effect derived from five included studies of HCV also supported a significant positive association between chronic HBV infection and GC development (pooled HR, 1.88; 95% CI, 1.28–2.76; P = 0.001; heterogeneity, I2 = 74.7%; P = 0.003). In conclusion, both chronic HBV and HCV infections were related to a high risk of GC. The plausible mechanisms underlying such association might be correlated to HBV/HCV infection-induced persistent inflammation, immune dysfunction, and cirrhosis.
Systematic Review RegistrationPROSPERO (http://www.crd.york.ac.uk/PROSPERO), identifier (CRD42021243719).
History
References
- https://doi.org//10.3322/caac.21660
- https://doi.org//10.1136/gutjnl-2019-320234
- https://doi.org//10.1093/jnci/djx262
- https://doi.org//10.1002/ijc.28999
- https://doi.org//10.3389/fonc.2020.561420
- https://doi.org//10.1007/s00408-020-00365-y
- https://doi.org//10.1097/MCG.0000000000001532
- https://doi.org//10.7150/jca.31033
- https://doi.org//10.4103/0973-1482.174544
- https://doi.org//10.1016/j.diagmicrobio.2018.04.015
- https://doi.org//10.1177/1756284819855732
- https://doi.org//10.31557/APJCP.2019.20.7.2177
- https://doi.org//10.1002/jmv.23754
- https://doi.org//10.1002/cam4.3901
- https://doi.org//10.1038/bjc.2014.406
- https://doi.org//10.1186/s12885-016-2918-5
- https://doi.org//10.1002/ijc.30719
- https://doi.org//10.1371/journal.pone.0193232
- https://doi.org//10.1016/j.canep.2018.05.012
- https://doi.org//10.1002/ijc.31643
- https://doi.org//10.1001/jamanetworkopen.2019.5718
- https://doi.org//10.1111/jvh.13304
- https://doi.org//10.1002/ijc.33130
- https://doi.org//10.14309/ajg.0000000000000606
- https://doi.org//10.1111/liv.14305
- https://doi.org//10.1042/BSR20190691
- https://doi.org//10.1080/17437199.2020.1762106
- https://doi.org//10.1016/j.bbcan.2017.05.006
- https://doi.org//10.15585/mmwr.mm6921a2
- https://doi.org//10.1080/00365521.2020.1868568
- https://doi.org//10.1002/jmv.25584
- https://doi.org//10.1186/s13027-016-0076-7
- https://doi.org//10.14309/ctg.0000000000000201
- https://doi.org//10.1186/s12967-019-1841-3
- https://doi.org//10.1038/nature24302
- https://doi.org//10.1038/nature01322
- https://doi.org//10.1038/bjc.2013.689
- https://doi.org//10.1016/j.aogh.2014.09.013
- https://doi.org//10.1016/j.diagmicrobio.2018.04.015
- https://doi.org//10.1016/j.jhep.2007.11.009
- https://doi.org//10.1002/hep.26385
- https://doi.org//10.1097/00008469-200306000-00002
- https://doi.org//10.3748/wjg.v20.i4.1107
- https://doi.org//10.1097/MD.0000000000002871
- https://doi.org//10.1097/MEG.0000000000000220
- https://doi.org//10.1111/j.1572-0241.1999.01360.x
- https://doi.org//10.1007/978-3-642-38965-8_2
- https://doi.org//10.3748/wjg.v21.i45.12896
- https://doi.org//10.1002/prca.200800059
- https://doi.org//10.1053/j.gastro.2015.08.035
- https://doi.org//10.1016/j.ccell.2020.06.001
- https://doi.org//10.1038/nrgastro.2017.172
CC BY 4.0