Table_1_The Association Between Leukocyte Telomere Length and Cognitive Performance Among the American Elderly.DOCX (76.99 kB)

Table_1_The Association Between Leukocyte Telomere Length and Cognitive Performance Among the American Elderly.DOCX

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posted on 30.10.2020, 05:00 by Deng Linghui, Qiu Shi, Chen Chi, Liu Xiaolei, Zhou Lixing, Zuo Zhiliang, Dong Birong
Background

Age-related cognitive decline begins in middle age and persists with age. Leukocyte telomere length (LTL) decreases with age and is enhanced by inflammation and oxidative stress. However, whether shorter LTL correlates with cognitive decline remains controversial.

Aims

We aimed to investigate the relationship between LTL and cognitive decline in the American elderly.

Methods

We used data from the 1999 to 2002 U.S. National Health and Nutrition Examination Survey (NHANES). We included participants aged 65–80 with available data on LTL and cognitive assessments. The cognitive function assessment used the digit symbol substitution test (DSST). We applied multivariate modeling to estimate the association between LTL and cognitive performance. Additionally, to ensure robust data analysis, we converted LTL into categorical variables through quartile and then calculated the P for trend.

Results

After adjusting for age, cardiovascular disease (CAD) score, gender, race, body mass index (BMI), and educational level, LTL showed a positive correlation with DSST score (odds ratio [OR] 3.47 [0.14, 6.79], P = 0.04). Additionally, to further quantify the LTL–DSST interaction, we found a similar trend when LTL was regarded as a categorical variable (quartile) (P for trend = 0.03).

Conclusion

LTL was associated with cognitive capabilities among the elderly, implying that LTL might be a biomarker of cognitive aging.

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