Table_1_Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center.XLSX
Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis.
MethodsThe clinical data from children with high-risk HB or HB tumor rupture at our institution from October 2008 to 2017 were retrospectively reviewed and analyzed.
ResultsTogether, 34 children with high-risk HB or HB tumor rupture were retrospected, including 25 in the high-risk group and nine in tumor rupture group. The 3-year overall survival (OS) rate in tumor rupture group was significantly higher than that of the high-risk group (100 vs. 64%, p = 0.0427). In tumor rupture group, seven (77.8%) of nine patients had a hemoglobin level ≤ 8 g/L and 3 of them (33.3%) had ≤ 6 g/L at the time of diagnosis. Peritoneal perfusion with interleukin-2 was implemented for each patient. At the end of the treatment, seven (77.8%) of nine patients achieved complete response (CR). No patient died at the last follow-up.
ConclusionsHB tumor rupture might not be predictive of poor prognosis with the risk of peritoneal dissemination/relapse, in which peritoneal perfusion with interleukin-2 could play a role.
History
References
- https://doi.org//10.1053/jhep.2003.50375
- https://doi.org//10.1016/S1470-2045(13)70272-9
- https://doi.org//10.1007/s00595-004-2766-9
- https://doi.org//10.1007/s00383-006-1827-0
- https://doi.org//10.1200/JCO.2009.22.4857
- https://doi.org//10.1016/j.ejca.2015.09.023
- https://doi.org//10.1016/j.ejca.2003.06.003
- https://doi.org//10.1007/s00383-010-2708-0
- https://doi.org//10.1002/cncr.24667
- https://doi.org//10.1007/s00247-018-4078-z
- https://doi.org//10.1007/s00247-006-0361-5
- https://doi.org//10.1056/NEJMoa0810613
- https://doi.org//10.1002/pbc.28549
- https://doi.org//10.1002/cncr.10632
- https://doi.org//10.1002/pbc.22088
- https://doi.org//10.1007/s00383-016-4046-3
- https://doi.org//10.1002/1097-0142(19930615)71%3A12<4067%3A%3AAID-CNCR2820711243>3.0.CO;2-D
- https://doi.org//10.1186/s12885-018-4581-5
- https://doi.org//10.1186/s12885-021-09041-7
- https://doi.org//10.1007/BF00730624
- https://doi.org//10.1111/j.1365-2141.2004.05094.x