Table_1_Rat Hepatitis E Virus: Presence in Humans in South-Western France?.xlsx (35.44 kB)
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Table_1_Rat Hepatitis E Virus: Presence in Humans in South-Western France?.xlsx

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posted on 03.09.2021, 04:50 by Delphine Parraud, Sébastien Lhomme, Jean Marie Péron, Isabelle Da Silva, Suzanne Tavitian, Nassim Kamar, Jacques Izopet, Florence Abravanel

Background: Hepatitis E Virus (HEV) is one of the most common causes of hepatitis worldwide, and South-Western France is a high HEV seroprevalence area. While most cases of HEV infection are associated with the species Orthohepevirus-A, several studies have reported a few cases of HEV infections due to Orthohepevirus-C (HEV-C) that usually infects rats. Most of these human cases have occurred in immunocompromised patients. We have screened for the presence of HEV-C in our region.

Methods and Results: We tested 224 sera, mostly from immunocompromised patients, for HEV-C RNA using an in-house real time RT-PCR. Liver function tests gave elevated results in 63% of patients: mean ALT was 159 IU/L (normal < 40 IU/L). Anti-HEV IgG (49%) and anti-HEV IgM (9.4%) were frequently present but none of the samples tested positive for HEV-C RNA.

Conclusion: HEV-C does not circulate in the human population of South-Western France, despite the high seroprevalence of anti-HEV IgG.

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