Table_1_MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes.xlsx
Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history of repeated reactivation and in memory Th cells isolated from the synovial fluid of patients with rheumatic joint disease. Knock-down of miR-31 resulted in the upregulation of genes associated with cytoskeletal rearrangement and motility and induced the expression of target genes involved in T cell activation, chemokine receptor– and integrin-signaling. Accordingly, inhibition of miR-31 resulted in increased migratory activity of repeatedly activated Th1 cells. The transcription factors T-bet and FOXO1 act as positive and negative regulators of T cell receptor (TCR)–mediated miR-31 expression, respectively. Taken together, our data show that a gene regulatory network involving miR-31, T-bet, and FOXO1 controls the migratory behavior of proinflammatory Th1 cells.
History
References
- https://doi.org//10.3389/fimmu.2015.00384
- https://doi.org//10.1002/1529-0131(199809)41:9<1669::AID-ART19>3.0.CO;2-G
- https://doi.org//10.1136/ard.2007.080341
- https://doi.org//10.1084/jem.20072468
- https://doi.org//10.1002/eji.201444633
- https://doi.org//10.1016/j.jaut.2017.11.005
- https://doi.org//10.1172/JCI119178
- https://doi.org//10.4049/jimmunol.165.6.3423
- https://doi.org//10.1038/ni1534
- https://doi.org//10.1513/pats.200606-137MS
- https://doi.org//10.3389/fimmu.2015.00586
- https://doi.org//10.1182/blood-2011-08-370536
- https://doi.org//10.1002/eji.201747354
- https://doi.org//10.1371/journal.pone.0095514
- https://doi.org//10.1038/nri3494
- https://doi.org//10.1002/eji.201344323
- https://doi.org//10.1002/eji.201646632
- https://doi.org//10.1038/ncomms9576
- https://doi.org//10.1038/nature04303
- https://doi.org//10.1016/j.jim.2015.07.006
- https://doi.org//10.1186/gb-2013-14-4-r36
- https://doi.org//10.1038/nmeth.1923
- https://doi.org//10.7554/eLife.05005
- https://doi.org//10.1038/ni.3755
- https://doi.org//10.1038/nbt.1754
- https://doi.org//10.1093/bib/bbs017
- https://doi.org//10.1016/j.cell.2012.09.044
- https://doi.org//10.1016/j.immuni.2011.07.015
- https://doi.org//10.1093/nar/gkw983
- https://doi.org//10.1093/nar/gkh355
- https://doi.org//10.1093/nar/gkj143
- https://doi.org//10.1016/j.immuni.2010.06.003
- https://doi.org//10.1016/j.immuni.2011.11.012
- https://doi.org//10.1016/j.immuni.2015.01.017
- https://doi.org//10.1101/gr.1239303
- https://doi.org//10.1093/bioinformatics/btg405
- https://doi.org//10.1073/pnas.0506580102
- https://doi.org//10.1038/ng1180
- https://doi.org//10.1038/ncomms8639
- https://doi.org//10.1126/science.1155390
- https://doi.org//10.1093/nar/gkw937
- https://doi.org//10.4049/jimmunol.1601160
- https://doi.org//10.1016/j.autrev.2012.10.001
- https://doi.org//10.1101/gr.229102
- https://doi.org//10.1038/ni.1689
- https://doi.org//10.1016/j.cell.2009.01.002
- https://doi.org//10.1093/bioinformatics/btp565
- https://doi.org//10.1084/jem.20111717
- https://doi.org//10.1038/nri.2016.40
- https://doi.org//10.1128/MCB.02005-06
- https://doi.org//10.1016/j.cell.2007.03.008
- https://doi.org//10.1038/jhg.2012.95
- https://doi.org//10.3892/or.2011.1555
- https://doi.org//10.1186/s13048-015-0186-7
- https://doi.org//10.1016/j.gene.2016.08.057
- https://doi.org//10.12659/MSM.898399
- https://doi.org//10.1016/j.bbrc.2017.06.050
- https://doi.org//10.1146/annurev.immunol.021908.132706
- https://doi.org//10.1016/j.immuni.2009.03.013
- https://doi.org//10.1038/ni.1945
- https://doi.org//10.4049/jimmunol.168.10.5024
- https://doi.org//10.1111/j.1749-6632.2011.06264.x
- https://doi.org//10.1016/j.immuni.2010.12.002
- https://doi.org//10.4049/jimmunol.181.5.2980
- https://doi.org//10.1002/eji.200939427
- https://doi.org//10.4049/jimmunol.1500626
- https://doi.org//10.1002/eji.201040936
- https://doi.org//10.1007/978-3-319-15774-0_10
- https://doi.org//10.1038/nature20810
- https://doi.org//10.1002/art.24754
- https://doi.org//10.1073/pnas.1118104109
Usage metrics
Read the peer-reviewed publication
Categories
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity