Table_1_LC-MS-Based Metabolomic Study of Oleanolic Acid-Induced Hepatotoxicity in Mice.xlsx (219.99 kB)

Table_1_LC-MS-Based Metabolomic Study of Oleanolic Acid-Induced Hepatotoxicity in Mice.xlsx

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posted on 26.05.2020, 04:14 by Hong Feng, Ying-Qiu Wu, Ya-Sha Xu, Ke-Xin Wang, Xue-Mei Qin, Yuan-Fu Lu

Oleanolic acid (OA), a natural triterpenoid, which has the development prospects in anti-tumor therapy is a widely used hepatoprotective drug in China. It has been reported that OA can cause liver toxicity after higher doses or longer-term use. Therefore, the study aims to explore the possible hepatotoxicity mechanism based on liver metabolic profiles. Liver metabolic profiles were obtained from untargeted ultrahigh performance liquid chromatography (UHPLC)-Q Exactive Orbitrap mass spectrometry (MS) technique. It was found that altered bile acid, amino acid, and energy metabolism might be at least partly responsible for OA-induced hepatotoxicity. Bile acid metabolism, as the most important pathway, was verified by using UHPLC-TSQ-MS, indicating that conjugated bile acids were the main contributors to OA-induced liver toxicity. Our findings confirmed that increased bile acids were the key element of OA hepatotoxicity, which may open new insights for OA hepatotoxicity in-depth investigations, as well as provide a reference basis for more hepatotoxic drug mechanism research.

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