Table_1_Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female.doc (18.85 kB)
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Table_1_Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female.doc

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posted on 20.07.2021, 04:30 authored by Prasanna Venkatesh Ramachandran, C. Mary Healy, Elton M. Lambert, Deyanara Guerra, Choladda V. Curry, Tiphanie P. Vogel

Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.

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