Table_1_Assigning the Absolute Configurations of Chiral Primary Amines Based on Experimental and DFT-Calculated 19F Nuclear Magnetic Resonance.docx (9.31 MB)

Table_1_Assigning the Absolute Configurations of Chiral Primary Amines Based on Experimental and DFT-Calculated 19F Nuclear Magnetic Resonance.docx

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posted on 20.05.2019 by Shiwei Yang, Guangling Bian, Rongjian Sa, Ling Song

In this work, a novel method for assigning the absolute configuration of a chiral primary amine has been developed based on the experimental and DFT-calculated 19F NMR chemical shift differences of its derived two fluorinated amides by reacting with two enantiomers of a chiral derivatizing agent FPP (α-fluorinated phenylacetic phenylselenoester) separately. Comparing the experimental chemical shift difference Δδα-FR,S of (R)-FPA-amide/(S)-FPA-amide with the calculated Δδα-FR,S of (R)-FPA-(R)-amide/(S)-FPA-(R)-amide, if the experimental Δδα-FR,S has the same symbol (positive or negative) as one of the theoretical Δδα-FR,S, the assigned configuration of the amine is considered to be consistent with the theoretical one. Our method could be applied to a broad substrate scope avoiding wrong conclusion due to empirical judgment.

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