Table_1_An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes.docx (355.09 kB)

Table_1_An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes.docx

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posted on 07.04.2020 by Alina-Andreea Zimta, Adrian Bogdan Tigu, Cornelia Braicu, Cristina Stefan, Calin Ionescu, Ioana Berindan-Neagoe

The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.

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