Table_1_A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy.DOCX (2.12 MB)
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Table_1_A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy.DOCX

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posted on 20.12.2019, 10:56 by Jing Hao Fan, Gui Ling Fan, Ping Yuan, Fu An Deng, Ling Shan Liu, Xiang Zhou, Xi Yong Yu, Hong Cheng, Shi Ying Li

Hypoxia is a common feature for most malignant tumors, which was also closely related to the oxygen-dependent photodynamic therapy. Based on Förster resonance energy transfer (FRET), a smart nanoprobe (designated as H-Probe) was designed in this paper for hypoxia imaging and photodynamic tumor therapy. Due to the FRET process, H-Probe could respond to hypoxia with a significant fluorescence recovery. Moreover, abundant in vitro investigations demonstrated that the photosensitizer of PpIX in H-Probe could generate large amounts of singlet oxygen to kill cancer cells in the presence of oxygen and light with appropriate wavelength. Also, intravenously injected H-Probe with light irradiation achieved an effective tumor inhibition in vivo with a reduced side effect. This original strategy of integrating hypoxia imaging and tumor therapy in one nanoplatform would promote the development of theranostic nanoplatform for tumor precision therapy.

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