Table3_Prediction of Two Molecular Subtypes of Gastric Cancer Based on Immune Signature.xlsx (956.5 kB)
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Table3_Prediction of Two Molecular Subtypes of Gastric Cancer Based on Immune Signature.xlsx

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posted on 17.01.2022, 15:30 authored by Dan Wu, Mengyao Feng, Hongru Shen, Xilin Shen, Jiani Hu, Jilei Liu, Yichen Yang, Yang Li, Meng Yang, Wei Wang, Qiang Zhang, Fangfang Song, Ben Liu, Kexin Chen, Xiangchun Li

Gastric cancer is the fifth most common type of human cancer and the third leading cause of cancer-related death. The purpose of this study is to investigate the immune infiltration signatures of gastric cancer and their relation to prognosis. We identified two distinct subtypes of gastric cancer (C1/C2) characterized by different immune infiltration signatures. C1 is featured by immune resting, epithelial–mesenchymal transition, and angiogenesis pathways, while C2 is featured by enrichment of the MYC target, oxidative phosphorylation, and E2F target pathways. The C2 subtype has a better prognosis than the C1 subtype (HR = 0.61, 95% CI: 0.44–0.85; log-rank test, p = 0.0029). The association of C1/C2 with prognosis remained statistically significant (HR = 0.62, 95% CI: 0.44–0.87; p = 0.006) after controlling for age, gender, and stage. The prognosis prediction of C1/C2 was verified in four independent cohorts (including an internal cohort). In summary, our study is helpful for better understanding of the association between immune infiltration and the prognosis of gastric cancer.

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