Data_Sheet_6_Chronic Kidney Diseases and Acute Kidney Injury in Patients With COVID-19: Evidence From a Meta-Analysis.PDF
Renal involvement has been implicated in coronavirus disease 2019 (COVID-19), but the related prevalence and prognosis were largely unknown. In this meta-analysis, we searched the literature from PubMed, Embase, through bioRxiv, and medRxiv until April 26, 2020. Studies reporting chronic kidney diseases (CKDs) and/or acute kidney injury (AKI) were included. Demographics, relevant data of disease severity, and patient's prognosis were extracted and aggregated. Twenty-one thousand one hundred sixty-four patients from 52 peer-reviewed studies were included. Thirty-seven studies (n = 16,922) reported CKD in COVID-19 patients at diagnosis, and the pooled prevalence was 3.52% (95% CI, 1.98–5.48%; I2 = 93%). Subgroup analysis showed that CKD prevalence was higher in severe cases [odds ratio (OR), 3.42; 95% CI 2.05–5.61; I2 = 0%] compared to those with non-severe disease and deceased cases (6.46, 3.40–12.29; I2 = 1%) compared with survivors. Pooled prevalence of CKD was lower in Chinese patients (2.56%; 95% CI, 1.79–3.47%; I2 = 80%) compared to those outside of China (6.32%; 95% CI, 0.9–16.12%; I2 = 93%) (p = 0.08). The summary estimates for AKI prevalence was 11.46% (95% CI, 6.93–16.94%). Patients with AKI had a higher prevalence of developing into severe cases (OR, 6.97; 95% CI, 3.53–13.75; I2 = 0%) and mortality risk (45.79, 36.88–56.85; I2 = 17%). The prevalence estimates of CKD or AKI were not significantly different from preprint publications (p > 0.05). Our study indicates that renal condition, either in CKD or AKI, is associated with COVID-19 prognosis, and taking care of such patients needs further awareness and investigations.
History
References
- https://doi.org//10.1002/jmv.25735
- https://doi.org//10.1056/NEJMoa2002032
- https://doi.org//10.1016/S2213-2600(20)30079-5
- https://doi.org//10.1681/ASN.2020030276
- https://doi.org//10.1016/j.kint.2020.03.005
- https://doi.org//10.1016/j.kint.2020.04.003
- https://doi.org//10.1136/bmj.m1091
- https://doi.org//10.46234/ccdcw2020.032
- https://doi.org//10.1016/j.ijid.2020.03.017
- https://doi.org//10.1016/S0140-6736(20)30045-3
- https://doi.org//10.1016/S0140-6736(13)60687-X
- https://doi.org//10.1038/s41581-018-0052-0
- https://doi.org//10.1038/nrneph.2013.146
- https://doi.org//10.18632/aging.103000
- https://doi.org//10.20452/pamw.15312
- https://doi.org//10.1001/jamacardio.2020.1624
- https://doi.org//10.1111/cts.12805
- https://doi.org//10.1016/j.jcv.2020.104364
- https://doi.org//10.1016/j.cmi.2020.04.012
- https://doi.org//10.1016/j.jhin.2020.04.019
- https://doi.org//10.1016/j.jaci.2020.04.006
- https://doi.org//10.1002/jmv.25891
- https://doi.org//10.1053/j.gastro.2020.04.008
- https://doi.org//10.1017/ice.2020.126
- https://doi.org//10.1093/gerona/glaa089
- https://doi.org//10.1164/rccm.202003-0736LE
- https://doi.org//10.1001/jama.2020.5394
- https://doi.org//10.1136/gutjnl-2020-321013
- https://doi.org//10.1016/j.jinf.2020.03.019
- https://doi.org//10.1093/cid/ciaa243
- https://doi.org//10.1002/dmrr.3319
- https://doi.org//10.1016/j.chest.2020.03.032
- https://doi.org//10.1056/NEJMoa2005412
- https://doi.org//10.1001/jamacardio.2020.1017
- https://doi.org//10.1172/JCI137244
- https://doi.org//10.1001/jama.2020.4326
- https://doi.org//10.1186/s13054-020-2833-7
- https://doi.org//10.1016/j.jinf.2020.03.005
- https://doi.org//10.1001/jamainternmed.2020.0994
- https://doi.org//10.1111/all.14238
- https://doi.org//10.1007/s11427-020-1643-8
- https://doi.org//10.1001/jama.2020.1585
- https://doi.org//10.1016/S0140-6736(20)30183-5
- https://doi.org//10.1136/bmj.m606
- https://doi.org//10.1016/S0140-6736(20)30566-3
- https://doi.org//10.1002/alr.22592
- https://doi.org//10.1038/s41591-020-0877-5
- https://doi.org//10.1001/jama.2020.6775
- https://doi.org//10.1016/j.chest.2020.04.010
- https://doi.org//10.1161/CIRCRESAHA.120.317134
- https://doi.org//10.3760/cma.j.cn112147-20200224-00168
- https://doi.org//10.1164/rccm.202002-0445OC
- https://doi.org//10.1183/13993003.00562-2020
- https://doi.org//10.1513/AnnalsATS.202003-225OC
- https://doi.org//10.1164/rccm.202003-0543OC
- https://doi.org//10.3346/jkms.2020.35.e142
- https://doi.org//10.3346/jkms.2020.35.e132
- https://doi.org//10.1056/NEJMoa2004500
- https://doi.org//10.1016/S1473-3099(20)30200-0
- https://doi.org//10.1136/gutjnl-2020-320926
- https://doi.org//10.1093/cid/ciaa322
- https://doi.org//10.1186/s12882-018-1072-5
- https://doi.org//10.7326/0003-4819-134-8-200104170-00007
- https://doi.org//10.1053/j.ajkd.2020.03.009
- https://doi.org//10.1016/S0140-6736(20)30628-0
- https://doi.org//10.1016/j.clinbiochem.2020.04.008
- https://doi.org//10.1016/S0140-6736(20)30691-7
- https://doi.org//10.1111/ajt.15891
- https://doi.org//10.1016/j.kint.2017.06.030
- https://doi.org//10.1093/ndt/gfu185
- https://doi.org//10.1186/1471-2369-13-51
- https://doi.org//10.1016/j.phrs.2020.105107
- https://doi.org//10.14336/AD.2020.0520
- https://doi.org//10.1186/s13054-020-03065-4
- https://doi.org//10.1016/j.ekir.2020.06.013
- https://doi.org//10.1038/kisup.2012.1
- https://doi.org//10.1159/000339789
- https://doi.org//10.1164/rccm.201908-1581ST
- https://doi.org//10.1007/s10654-010-9491-z
Usage metrics
Read the peer-reviewed publication
Categories
- Radiology and Organ Imaging
- Foetal Development and Medicine
- Obstetrics and Gynaecology
- Medical Genetics (excl. Cancer Genetics)
- Medical and Health Sciences not elsewhere classified
- Dermatology
- Emergency Medicine
- Gastroenterology and Hepatology
- Geriatrics and Gerontology
- Intensive Care
- Primary Health Care
- Nephrology and Urology
- Nuclear Medicine
- Orthopaedics
- Otorhinolaryngology
- Pathology (excl. Oral Pathology)
- Family Care