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Data_Sheet_2_Genetic comparison of transmissible gastroenteritis coronaviruses.PDF (840 kB)

Data_Sheet_2_Genetic comparison of transmissible gastroenteritis coronaviruses.PDF

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posted on 2023-04-17, 04:19 authored by Pei-Hua Wang, Amina Nawal Bahoussi, Pir Tariq Shah, Yan-Yan Guo, Changxin Wu, Li Xing

Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that threatens animal health and remains elusive despite years of research efforts. The systematical analysis of all available full-length genomes of TGEVs (a total of 43) and porcine respiratory coronaviruses PRCVs (a total of 7) showed that TGEVs fell into two independent evolutionary phylogenetic clades, GI and GII. Viruses circulating in China (until 2021) clustered with the traditional or attenuated vaccine strains within the same evolutionary clades (GI). In contrast, viruses latterly isolated in the USA fell into GII clade. The viruses circulating in China have a lower similarity with that isolated latterly in the USA all through the viral genome. In addition, at least four potential genomic recombination events were identified, three of which occurred in GI clade and one in GII clade. TGEVs circulating in China are distinct from the viruses latterly isolated in the USA at either genomic nucleotide or antigenic levels. Genomic recombination serves as a factor driving the expansion of TGEV genomic diversity.

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