Data_Sheet_2_Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India.PDF (103.58 kB)
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Data_Sheet_2_Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India.PDF

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posted on 25.09.2020, 11:31 by Anshika Srivastava, Audditiya Bandopadhyay, Debashurti Das, Rudra Kumar Pandey, Vanya Singh, Nargis Khanam, Nikhil Srivastava, Prajjval Pratap Singh, Pavan Kumar Dubey, Abhishek Pathak, Pranav Gupta, Niraj Rai, Gazi Nurun Nahar Sultana, Gyaneshwer Chaubey

Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. We trust that this information will be useful to understand the role of ACE2 in COVID-19 susceptibility.

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