Data_Sheet_1_Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.PDF (6.26 MB)
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Data_Sheet_1_Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.PDF

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posted on 13.05.2020, 04:43 authored by Meng Zhao, Yi Xiao, Satoshi Otsuka, Yoichi Nakao, Yian Guo, Tao Ye

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

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