Data_Sheet_1_Testing Multi-Task Cancer Evolution: How Do We Test Ecological Hypotheses in Cancer?.PDF
Recently several authors described a family of models, according to which different cancer types and subtypes fall within a space of selective trade-offs between archetypes that maximize the performance of different tasks: cell division, biomass and energy production, lipogenesis, immune interaction, and invasion and tissue remodeling. On this picture, inter- and intratumor heterogeneity can be explained in part as a product of these selective trade-offs in different cancers, at different stages of cancer progression. The aim of this Perspective is to critically assess this approach. I use this case study to consider more generally both the advantages of using ecological models in the context of cancer, and the challenges facing testing of such models.
History
References
- https://doi.org//10.1016/j.coisb.2019.09.001
- https://doi.org//10.1016/j.cels.2018.12.008
- https://doi.org//10.1038/nrc3606
- https://doi.org//10.1096/fasebj.2.7.3350243
- https://doi.org//10.1515/9780691186863
- https://doi.org//10.1148/radiol.2017160728
- https://doi.org//10.1038/s41598-019-39636-x
- https://doi.org//10.1200/JCO.2003.05.063
- https://doi.org//10.1227/00006123-199604000-00026
- https://doi.org//10.1002/(SICI)1097-0215(19960717)67%3A2<275%3A%3AAID-IJC20>3.0.CO;2-9
- https://doi.org//10.1038/s41568-018-0030-7
- https://doi.org//10.4161/cc.9.14.12248
- https://doi.org//10.1038/nature10762
- https://doi.org//10.1016/j.cell.2011.02.013
- https://doi.org//10.1093/imammb/dqq011
- https://doi.org//10.1038/s41568-020-0241-6
- https://doi.org//10.1038/s41467-019-13195-1
- https://doi.org//10.1016/j.cell.2018.03.042
- https://doi.org//10.1158/0008-5472.CAN-12-2215
- https://doi.org//10.1007/s10539-018-9629-z
- https://doi.org//10.1182/blood.2020008407
- https://doi.org//10.1038/nrc.2017.69
- https://doi.org//10.1038/nrc2013
- https://doi.org//10.1038/nrc1295
- https://doi.org//10.1126/science.959840
- https://doi.org//10.1086/677956
- https://doi.org//10.1038/onc.2010.519
- https://doi.org//10.1038/42701
- https://doi.org//10.2307/2389364
- https://doi.org//10.1086/285685
- https://doi.org//10.1038/s41467-017-00367-0
- https://doi.org//10.1142/8973