Data_Sheet_1_Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity.PDF
Geranylated coumarin constituents, kayeassamin I (1) and mammeasins E (2) and F (3) were newly isolated from the methanol extract of the flowers of Mammea siamensis (Calophyllaceae) originating in Thailand, along with five known isolates, such as mammea E/BC (23), deacetylmammea E/AA cyclo D (31), deacetylmammea E/BB cyclo D (32), mammea A/AA cyclo F (34), and mammea A/AC cyclo F (35). These compounds (1–3) were obtained as an inseparable mixture (ca. 1:1 ratio) of the 3″R and 3″S forms, respectively. Among the isolated coumarins from the extract, mammeasins E (2, 22.6 μM), A (4, 19.0 μM), and B (5, 24.0 μM), kayeassamins E (9, 33.8 μM), F (10, 15.9 μM), and G (11, 17.7 μM), surangin C (13, 5.9 μM), and mammeas A/AA (17, 19.5 μM), E/BB (22, 16.8 μM), and A/AA cyclo F (34, 23.6 μM), were found to inhibit testosterone 5α-reductase.
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References
- https://doi.org//10.1016/j.steroids.2009.10.005
- https://doi.org//10.1155/2012/530121
- https://doi.org//10.1517/17425255.2010.495944
- https://doi.org//10.1159/000019895
- https://doi.org//10.1038/pcan.2008.56
- https://doi.org//10.1021/np000517o
- https://doi.org//10.1076/phbi.38.6.55.5954
- https://doi.org//10.1007/s11418-019-01311-w
- https://doi.org//10.1155/2015/853846
- https://doi.org//10.1139/v06-157
- https://doi.org//10.1590/S0103-50532007000500031
- https://doi.org//10.5478/MSL.2012.3.1.021
- https://doi.org//10.1021/np010579u
- https://doi.org//10.1177/1934578X0700200509
- https://doi.org//10.3390/molecules22122279
- https://doi.org//10.1248/bpb.24.586
- https://doi.org//10.1016/S0031-9422(98)00688-8
- https://doi.org//10.1007/s11418-017-1160-z
- https://doi.org//10.1016/j.bmc.2012.06.031
- https://doi.org//10.1248/cpb.58.1487
- https://doi.org//10.1248/cpb.c16-00218
- https://doi.org//10.1016/j.jep.2014.06.001
- https://doi.org//10.1016/j.bioorg.2019.01.029
- https://doi.org//10.1016/S0031-9422(97)00820-0
- https://doi.org//10.1076/phbi.38.6.58.5962
- https://doi.org//10.1248/cpb.54.884
- https://doi.org//10.1016/j.phytochem.2006.02.006
- https://doi.org//10.21010/ajtcam.v14i2.3
- https://doi.org//10.1002/slct.201802537
- https://doi.org//10.1021/acs.joc.8b00986
- https://doi.org//10.1016/j.tet.2017.06.016
- https://doi.org//10.1002/pros.22745
- https://doi.org//10.1067/mjd.2000.103272
- https://doi.org//10.1016/j.bmcl.2012.10.127
- https://doi.org//10.4103/0974-8490.188884
- https://doi.org//10.1016/j.phytochem.2004.07.001
- https://doi.org//10.1016/j.bmcl.2008.07.001
- https://doi.org//10.1016/j.bmc.2008.07.091
- https://doi.org//10.1517/14656566.2013.797965
- https://doi.org//10.5650/jos.55.173
- https://doi.org//10.1515/hmbci.2010.035
- https://doi.org//10.1055/s-2005-871257
- https://doi.org//10.1016/j.bmcl.2010.10.112
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- Geochemistry
- Biochemistry
- Organic Chemistry
- Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
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- Medical Biochemistry and Metabolomics not elsewhere classified
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