Data_Sheet_1_From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?.docx (390.4 kB)
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Data_Sheet_1_From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?.docx

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posted on 04.12.2018, 04:13 by Anne-Laure Bonnet, Catherine Chaussain, Isabelle Broutin, Gaël Y. Rochefort, Heinrich Schrewe, Céline Gaucher

First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.

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