Data_Sheet_1_Elevated Autoantibodies in Subacute Human Spinal Cord Injury Are Naturally Occurring Antibodies.PDF (225.45 kB)

Data_Sheet_1_Elevated Autoantibodies in Subacute Human Spinal Cord Injury Are Naturally Occurring Antibodies.PDF

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posted on 11.10.2018 by Angel Arevalo-Martin, Lukas Grassner, Daniel Garcia-Ovejero, Beatriz Paniagua-Torija, Gemma Barroso-Garcia, Alba G. Arandilla, Orpheus Mach, Angela Turrero, Eduardo Vargas, Monica Alcobendas, Carmen Rosell, Maria A. Alcaraz, Silvia Ceruelo, Rosa Casado, Francisco Talavera, Ramiro Palazón, Nuria Sanchez-Blanco, Doris Maier, Ana Esclarin, Eduardo Molina-Holgado

Spinal cord injury (SCI) results in long-term neurological and systemic consequences, including antibody-mediated autoimmunity, which has been related to impaired functional recovery. Here we show that autoantibodies that increase at the subacute phase of human SCI, 1 month after lesion, are already present in healthy subjects and directed against non-native proteins rarely present in the normal spinal cord. The increase of these autoantibodies is a fast phenomenon–their levels are already elevated before 5 days after lesion–characteristic of secondary immune responses, further supporting their origin as natural antibodies. By proteomics studies we have identified that the increased autoantibodies are directed against 16 different nervous system and systemic self-antigens related to changes known to occur after SCI, including alterations in neural cell cytoskeleton, metabolism and bone remodeling. Overall, in the context of previous studies, our results offer an explanation to why autoimmunity develops after SCI and identify novel targets involved in SCI pathology that warrant further investigation.

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