Data_Sheet_1_Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance.PDF (10.74 MB)

Data_Sheet_1_Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance.PDF

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posted on 19.09.2019, 04:17 by Xia Lu, Guantao Jin, Wenjin Chen, Xinguang Yu, Feng Ling

The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS.

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