Data_Sheet_1_DIlp7-Producing Neurons Regulate Insulin-Producing Cells in Drosophila.xlsx (72.64 kB)
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Data_Sheet_1_DIlp7-Producing Neurons Regulate Insulin-Producing Cells in Drosophila.xlsx

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posted on 27.07.2021, 05:08 by Elodie Prince, Jenny Kretzschmar, Laura C. Trautenberg, Susanne Broschk, Marko Brankatschk

Cellular Insulin signaling shows a remarkable high molecular and functional conservation. Insulin-producing cells respond directly to nutritional cues in circulation and receive modulatory input from connected neuronal networks. Neuronal control integrates a wide range of variables including dietary change or environmental temperature. Although it is shown that neuronal input is sufficient to regulate Insulin-producing cells, the physiological relevance of this network remains elusive. In Drosophila melanogaster, Insulin-like peptide7-producing neurons are wired with Insulin-producing cells. We found that the former cells regulate the latter to facilitate larval development at high temperatures, and to regulate systemic Insulin signaling in adults feeding on calorie-rich food lacking dietary yeast. Our results demonstrate a role for neuronal innervation of Insulin-producing cells important for fruit flies to survive unfavorable environmental conditions.

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