Data_Sheet_1_Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific.pdf
Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training.
Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan.
Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation.
Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently.
Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research.
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References
- https://doi.org//10.1007/s10875-019-00737-x
- https://doi.org//10.3389/fimmu.2019.03148
- https://doi.org//10.1016/B978-0-12-405546-9.00055-8
- https://doi.org//10.1016/j.aller.2014.05.007
- https://doi.org//10.1016/j.eurpsy.2005.05.001
- https://doi.org//10.1006/clim.1999.4799
- https://doi.org//10.1086/302547
- https://doi.org//10.1016/j.jaci.2017.09.004
- https://doi.org//10.1016/j.jaci.2012.11.033
- https://doi.org//10.1016/j.jaip.2019.02.004
- https://doi.org//10.1038/ejhg.2013.46
- https://doi.org//10.3389/fimmu.2020.00614
- https://doi.org//10.1111/j.1749-6632.2011.06225.x
- https://doi.org//10.3389/fimmu.2017.00808
- https://doi.org//10.3389/fimmu.2018.00289
- https://doi.org//10.3389/fimmu.2020.00464
- https://doi.org//10.1542/peds.2018-2300
- https://doi.org//10.1007/s10875-015-0152-6
- https://doi.org//10.1016/j.jaci.2004.10.012
- https://doi.org//10.1007/s00431-016-2746-2
- https://doi.org//10.1038/s41409-019-0554-9
- https://doi.org//10.1007/s13312-018-1354-9
- https://doi.org//10.1007/s10875-018-0542-7
- https://doi.org//10.1016/j.gendis.2019.09.004
- https://doi.org//10.3389/fimmu.2017.00714
- https://doi.org//10.3389/fimmu.2019.02111
- https://doi.org//10.1111/cei.13125
- https://doi.org//10.1038/ni0908-1005
- https://doi.org//10.1093/bioinformatics/btz525
- https://doi.org//10.1080/1744666X.2017.1255143
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Categories
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity
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