Data_Sheet_1_Association of Maternal Body Mass Index With Risk of Infant Mortality: A Dose-Response Meta-Analysis.docx
Objective: This study presumed that a high or low body mass index (BMI) might increase the risk of infant mortality. Therefore, a meta-analysis was performed to systematically assess the association between maternal BMI and the risk of infant mortality.
Methods: The electronic databases, including Pubmed, Embase database, and Cochrane Library, were systemically searched by two investigators from inception to November 26th, 2020, with no language restriction. In parallel, a dose-response was assessed.
Results: Finally, 22 cohort studies involving 13,532,293 participants were included into this paper, which showed that compared with normal BMI, maternal overweight significantly increased the risks of infant mortality [risk ratio (RR), 1.16; 95% confidence interval (CI), 1.13–1.19], neonatal mortality (RR, 1.23; 95% CI, 1.08–1.39), early neonatal mortality (RR, 1.55; 95% CI, 1.26–1.92) and post-neonatal mortality (RR, 1.18; 95% CI, 1.07–1.29). Similarly, maternal obesity significantly increased the risk of infant mortality (RR, 1.55; 95% CI, 1.41–1.70), neonatal mortality (RR, 1.55; 95% CI, 1.28–1.67), early neonatal mortality (RR, 1.37; 95% CI, 1.13–1.67), and post-neonatal mortality (RR, 1.30; 95% CI, 1.03–1.65), whereas maternal underweight potentially decreased the risk of infant mortality (RR, 0.93; 95% CI, 0.88–0.98). In the dose-response analysis, the risk of infant mortality significantly increased when the maternal BMI was >25 kg/m2.
Conclusions: Maternal overweight or obesity significantly increases the risks of infant mortality, neonatal mortality, early neonatal mortality, and post-neonatal mortality compared with normal BMI in a dose-dependent manner. Besides, maternal underweight will not increase the risk of infant mortality, neonatal mortality, early neonatal mortality, or postneonatal mortality; instead, it tends to decrease the risk of infant mortality. Early weight management may provide potential benefits to infants, and more large-scale prospective studies are needed to verify this finding in the future.
History
References
- https://doi.org//10.1016/j.nwh.2018.09.002
- https://doi.org//10.1001/jama.2018.3060
- https://doi.org//10.5402/2012/939762
- https://doi.org//10.3109/14767058.2014.987118
- https://doi.org//10.1186/1471-2393-14-201
- https://doi.org//10.1371/journal.pone.0082310
- https://doi.org//10.3109/14767058.2014.964675
- https://doi.org//10.1016/S0002-9378(03)00860-3
- https://doi.org//10.1097/00006250-200008000-00008
- https://doi.org//10.3390/ijerph15122737
- https://doi.org//10.1001/jama.283.15.2008
- https://doi.org//10.1001/jama.280.19.1690
- https://doi.org//10.1007/s10654-010-9491-z
- https://doi.org//10.1093/oxfordjournals.epirev.a036298
- https://doi.org//10.1016/j.jclinepi.2005.01.016
- https://doi.org//10.1097/XEB.0000000000000132
- https://doi.org//10.1002/sim.3013
- https://doi.org//10.1093/oxfordjournals.aje.a116237
- https://doi.org//10.1177/2047487318795194
- https://doi.org//10.1111/1471-0528.12443
- https://doi.org//10.1186/2047-783X-14-5-216
- https://doi.org//10.2105/AJPH.2005.074294
- https://doi.org//10.2105/AJPH.91.3.436
- https://doi.org//10.1097/01.AOG.0000107291.46159.00
- https://doi.org//10.1097/AOG.0000000000001241
- https://doi.org//10.1093/humrep/der052
- https://doi.org//10.1111/j.1471-0528.2005.00437.x
- https://doi.org//10.1111/j.1471-0528.2008.01931.x
- https://doi.org//10.1111/j.1600-0412.2011.01331.x
- https://doi.org//10.1136/bmj.g6572
- https://doi.org//10.1007/s10654-009-9375-2
- https://doi.org//10.1055/s-0037-1603826
- https://doi.org//10.5694/mja11.11120
- https://doi.org//10.1097/01.AOG.0000286760.46679.f8
- https://doi.org//10.1177/003335490812300410
- https://doi.org//10.1016/j.nut.2017.04.002
- https://doi.org//10.1097/AOG.0b013e318173ecd4
- https://doi.org//10.1515/jpm-2017-0384
- https://doi.org//10.1016/j.placenta.2012.05.006
- https://doi.org//10.1097/AOG.0000000000003677
- https://doi.org//10.1515/jpm-2019-0103
- https://doi.org//10.1542/peds.2013-1480
- https://doi.org//10.1001/jama.2014.2269
- https://doi.org//10.1097/AOG.0000000000001465
- https://doi.org//10.1111/obr.12455
- https://doi.org//10.1210/jc.2002-020311
- https://doi.org//10.1023/A:1012730325902
- https://doi.org//10.1053/sper.2002.29836
- https://doi.org//10.1067/S0002-9378(03)00576-3