Data_Sheet_1_Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children.csv
Autism spectrum disorder (ASD) is characterized by deficits in social interactions and repetitive, stereotypic behaviors. Evidence shows that bidirectional communication of the gut-brain axis plays an important role. Here, we recruited 62 patients with ASD in southern China, and performed a cross-sectional study to test the relationship between repeated behavior, gut microbiome composition, and alpha diversity. We divided all participants into two groups based on the clustering results of their microbial compositions and found Veillonella and Ruminococcus as the seed genera in each group. Repetitive behavior differed between clusters, and cluster 2 had milder repetitive symptoms than Cluster 1. Alpha diversity between clusters was significantly different, indicating that cluster 1 had lower alpha diversity and more severe repetitive, stereotypic behaviors. Repetitive behavior had a negative correlation with alpha diversity. We demonstrated that the difference in intestinal microbiome composition and altered alpha diversity can be associated with repetitive, stereotypic behavior in autism. The role of Ruminococcus and Veillonella in ASD is not yet understood.
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Categories
- Radiology and Organ Imaging
- Decision Making
- Autonomic Nervous System
- Cellular Nervous System
- Biological Engineering
- Central Nervous System
- Sensory Systems
- Neuroscience
- Endocrinology
- Artificial Intelligence and Image Processing
- Clinical Nursing: Tertiary (Rehabilitative)
- Image Processing
- Signal Processing
- Rehabilitation Engineering
- Biomedical Engineering not elsewhere classified
- Stem Cells
- Neurogenetics
- Developmental Biology
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