Data_Sheet_1_Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis.PDF (1.48 MB)

Data_Sheet_1_Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis.PDF

Download (1.48 MB)
dataset
posted on 30.10.2019 by Chun-Lan Xie, Jin-Mei Xia, Ting Lin, Ying-Jie Lin, Yu-Kun Lin, Man-Li Xia, Hai-Feng Chen, Zhu-Hua Luo, Zong-Ze Shao, Xian-Wen Yang

Two new (1, 2) and one known (3) meroterpenoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi. The relative structures of new compounds were determined on the basis of an extensive analysis of the NMR and MS data, and the absolute configurations were established by ECD calculations. Andrastone A (1) is a rare andrastin bearing an unusual cyclopentan-1,3-dione. It shows a selectively antiproliferative effect against HepG2 tumor cells with an IC50 value of 7.8 μM. Mechanism study showed that apoptosis via Caspase and RXRα pathways are responsible for the inhibitory effect.

History

Licence

Exports