Data_Sheet_1_A MicroRNA Derived From Schistosoma japonicum Promotes Schistosomiasis Hepatic Fibrosis by Targeting Host Secreted Frizzled-Related Protein 1.doc
Schistosomiasis remains a serious parasitic disease, which is characterized by granulomatous inflammation and hepatic fibrosis. MicroRNAs derived from parasites can regulate host genes and cell phenotype. Here, we showed that a miRNA derived from S. japonicum (Sja-miR-1) exists in the hepatic stellate cells (HSCs) of mice infected with the parasite and up-regulates the expression of collagens and α-SMA by targeting secreted frizzled-related protein 1 (SFRP1). A vector-mediated delivery of Sja-miR-1 into naive mice led to hepatic fibrogenesis in the mice. Accordingly, inhibition of Sja-miR-1 in the infected mice led to reduction of the parasite-induced hepatic fibrosis. The mechanism behind the Sja-miR-1-mediated activation of HSC could be through targeting SFRP1 to regulate the Wnt/β-catenin pathway. These findings reveal that parasite-derived small non-coding RNAs are implicated in cross-species regulation of host pathological process and persistent inhibition of Sja-miR-1 may provide a therapeutic potential for the parasite diseases.
History
References
- https://doi.org//10.1016/j.pt.2012.09.005
- https://doi.org//10.1016/S0092-8674(04)00045-5
- https://doi.org//10.1016/j.ijpara.2006.04.015
- https://doi.org//10.1016/j.addr.2017.05.016
- https://doi.org//10.1016/j.cardiores.2006.06.025
- https://doi.org//10.1038/ncomms6488
- https://doi.org//10.1111/j.1365-3024.2009.01098.x
- https://doi.org//10.1371/journal.pone.0064003
- https://doi.org//10.1172/JCI7325
- https://doi.org//10.1016/S0140-6736(13)61949-2
- https://doi.org//10.1038/nmeth1079
- https://doi.org//10.1053/j.gastro.2008.03.003
- https://doi.org//10.1038/nrgastro.2010.97
- https://doi.org//10.1007/s00436-015-4468-1
- https://doi.org//10.1016/j.jhep.2019.10.029
- https://doi.org//10.1002/hep.27671
- https://doi.org//10.3389/fonc.2019.00175
- https://doi.org//10.1242/jcs.00089
- https://doi.org//10.1016/j.jhep.2006.03.016
- https://doi.org//10.1002/bies.10136
- https://doi.org//10.1371/journal.pone.0090308
- https://doi.org//10.1073/pnas.1201840109
- https://doi.org//10.1186/1479-5876-9-9
- https://doi.org//10.1371/journal.ppat.1007817
- https://doi.org//10.1371/journal.pone.0003420
- https://doi.org//10.1074/jbc.M114.584565
- https://doi.org//10.1038/nrg1427
- https://doi.org//10.1016/j.febslet.2007.05.050
- https://doi.org//10.1128/JVI.79.1.214-224.2005
- https://doi.org//10.1038/nri843
- https://doi.org//10.1038/nature03319
- https://doi.org//10.1002/hep.27332
- https://doi.org//10.1161/CIRCHEARTFAILURE.114.001274
- https://doi.org//10.1038/nrmicro.2016.110
- https://doi.org//10.1002/hep.21651
- https://doi.org//10.1016/S0008-6363(02)00221-3
- https://doi.org//10.1038/nplants.2016.151
- https://doi.org//10.1038/sj.icb.7100014
- https://doi.org//10.1002/ijc.24518
- https://doi.org//10.1038/cr.2011.158
- https://doi.org//10.1038/srep25885
- https://doi.org//10.1186/s13071-016-1845-2