DataSheet_1_Whole-Transcriptome Profiling and circRNA-miRNA-mRNA Regulatory Networks in B-Cell Development.zip
The generation and differentiation of B lymphocytes (B cells) is a flexible process with many critical regulatory factors. Previous studies indicated that non-coding RNAs play multiple roles in the development of lymphocytes. However, little has been known about the circular RNA (circRNA) profiles and their competing endogenous RNA (ceRNA) networks in B-cell development and differentiation. Here, four B-cell subsets were purified from single-cell suspensions of mouse bone marrow. Then RNA sequencing (RNA-Seq) was used to display expression profiles of circRNAs, miRNAs and mRNAs during B-cell differentiation. 175, 203, 219 and 207 circRNAs were specifically expressed in pro-B cells, pre-B cells, immature B cells and mature B cells, respectively. The circRNA-associated ceRNA networks constructed in two sequential stages of B-cell differentiation revealed the potential mechanism of circRNAs in these processes. This study is the first to explore circRNA profiles and circRNA-miRNA-mRNA networks in different B-cell developmental stages of mouse bone marrow, which contribute to further research on their mechanism in B-cell development and differentiation.
History
References
- https://doi.org//10.1038/newbio234251a0
- https://doi.org//10.1038/205143a0
- https://doi.org//10.1038/nri3801
- https://doi.org//10.1016/j.stem.2018.04.015
- https://doi.org//10.3389/fimmu.2020.00045
- https://doi.org//10.1111/imm.13176
- https://doi.org//10.1146/annurev-genet-110410-132552
- https://doi.org//10.1182/blood-2008-02-078071
- https://doi.org//10.1146/annurev.immunol.19.1.595
- https://doi.org//10.1016/j.ceb.2017.10.002
- https://doi.org//10.1261/rna.068692.118
- https://doi.org//10.1038/nature11928
- https://doi.org//10.1016/j.molcel.2018.06.034
- https://doi.org//10.1016/j.cell.2018.12.021
- https://doi.org//10.1038/s41568-020-00306-0
- https://doi.org//10.7150/thno.29678
- https://doi.org//10.1002/jcp.27384
- https://doi.org//10.1016/j.pneurobio.2020.101746
- https://doi.org//10.1038/nature11993
- https://doi.org//10.1158/0008-5472.CAN-13-1568
- https://doi.org//10.1158/1078-0432.CCR-16-2541
- https://doi.org//10.1126/science.aam8526
- https://doi.org//10.1186/s12943-018-0827-8
- https://doi.org//10.3390/cancers13040593
- https://doi.org//10.1182/blood-2015-11-680843
- https://doi.org//10.4049/jimmunol.2000088
- https://doi.org//10.1111/imr.13024
- https://doi.org//10.1016/j.celrep.2020.108436
- https://doi.org//10.1016/j.celrep.2021.109390
- https://doi.org//10.1002/eji.201847660
- https://doi.org//10.1038/nri1633
- https://doi.org//10.1042/BCJ20180565
- https://doi.org//10.1016/j.exger.2020.110985
- https://doi.org//10.1182/blood.2020009564
- https://doi.org//10.3389/fimmu.2021.779085
- https://doi.org//10.1016/j.imlet.2019.09.004
- https://doi.org//10.1073/pnas.1606297113
- https://doi.org//10.3389/fgene.2021.678084
- https://doi.org//10.1038/s41374-018-0108-6
- https://doi.org//10.1182/blood-2008-10-184077
- https://doi.org//10.1182/blood-2008-09-178186
- https://doi.org//10.1038/nsmb.2959
- https://doi.org//10.1172/JCI7696
- https://doi.org//10.1182/bloodadvances.2018016162
- https://doi.org//10.1016/j.molcel.2010.07.031
- https://doi.org//10.1038/s41576-019-0158-7
- https://doi.org//10.1093/nar/gks957
- https://doi.org//10.1038/ni0203-101
- https://doi.org//10.1002/%28SICI%291521-4141%28199910%2929%3A10%3C3160%3A%3AAID-IMMU3160%3E3.0.CO;2-S
- https://doi.org//10.1128/CDLI.12.6.705-712.2005
- https://doi.org//10.4049/jimmunol.174.11.6974
- https://doi.org//10.4049/jimmunol.169.7.3526
- https://doi.org//10.4049/jimmunol.175.11.7103
- https://doi.org//10.1016/j.immuni.2013.04.005
- https://doi.org//10.1038/nature21076
- https://doi.org//10.1111/imr.12855
- https://doi.org//10.1586/1744666X.2016.1114885
Usage metrics
Read the peer-reviewed publication
Categories
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity
CC BY 4.0