DataSheet2_Discovery of Polyoxypregnane Derivatives From Aspidopterys obcordata With Their Potential Antitumor Activity.ZIP (6.8 MB)
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posted on 2022-01-05, 04:20 authored by Hong-Wei Guo, Yun-Gang Tian, Yi-Han Liu, Jia Huang, Jian-Xia Wang, Hua Long, Hua WeiThe bioassay-guided phytochemical study of an ethnic medicinal plant Aspidopterys obcorda ta Hemsl. var. obcordata results in the isolation of eight new polyoxypregnane derivatives, named aspidatasides A–H (1–8), along with ten known analogs (9–18). The series polyoxypregnane derivatives were screened for their cytoxic activity against HL-60 cells, and compound 2 showed the highest potency with an IC50 8.03 μM. Preliminary structure–activity relationship studies displayed that the sugar chain and double bond could notably impact their biological activity.
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Categories
- Geochemistry
- Biochemistry
- Inorganic Chemistry
- Organic Chemistry
- Nuclear Chemistry
- Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
- Medical Biochemistry and Metabolomics not elsewhere classified
- Environmental Chemistry (incl. Atmospheric Chemistry)
- Analytical Biochemistry
- Cell Neurochemistry
- Electroanalytical Chemistry
- Enzymes
- Organic Green Chemistry
- Physical Organic Chemistry
- Catalysis and Mechanisms of Reactions
- Analytical Chemistry not elsewhere classified
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- Environmental Chemistry
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