DataSheet1_A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2.PDF (117 kB)
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DataSheet1_A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2.PDF

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posted on 20.08.2021, 05:42 by Chao Yuan, Yuhua Guo, Ke Wang, Zhunian Wang, Longfei Li, Huajie Zhu, Gang Li

Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of 3, two compound 2-derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound 1. Compound 3 represents the first example of azaphilone heterotrimers.

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