10.3389/fnmol.2019.00250.s004
Yeonsoo Choi
Yeonsoo
Choi
Haram Park
Haram
Park
Suwon Kang
Suwon
Kang
Hwajin Jung
Hwajin
Jung
Hanseul Kweon
Hanseul
Kweon
Seoyeong Kim
Seoyeong
Kim
Ilsong Choi
Ilsong
Choi
Soo Yeon Lee
Soo Yeon
Lee
Ye-Eun Choi
Ye-Eun
Choi
Seung-Hee Lee
Seung-Hee
Lee
Eunjoon Kim
Eunjoon
Kim
Image_4_NGL-1/LRRC4C-Mutant Mice Display Hyperactivity and Anxiolytic-Like Behavior Associated With Widespread Suppression of Neuronal Activity.JPEG
Frontiers
2019
NGL-1
LRRC4C
synaptic adhesion molecule
hyperactivity
anxiety
learning and memory
synaptic transmission
intrinsic neuronal excitability
2019-10-11 09:22:10
Figure
https://frontiersin.figshare.com/articles/figure/Image_4_NGL-1_LRRC4C-Mutant_Mice_Display_Hyperactivity_and_Anxiolytic-Like_Behavior_Associated_With_Widespread_Suppression_of_Neuronal_Activity_JPEG/9970226
<p>Netrin-G ligand-1 (NGL-1), encoded by Lrrc4c, is a post-synaptic adhesion molecule implicated in various brain disorders, including bipolar disorder, autism spectrum disorder, and developmental delay. Although previous studies have explored the roles of NGL-1 in the regulation of synapse development and function, the importance of NGL-1 for specific behaviors and the nature of related neural circuits in mice remain unclear. Here, we report that mice lacking NGL-1 (Lrrc4c<sup>–/–</sup>) show strong hyperactivity and anxiolytic-like behavior. They also display impaired spatial and working memory, but normal object-recognition memory and social interaction. c-Fos staining under baseline and anxiety-inducing conditions revealed suppressed baseline neuronal activity as well as limited neuronal activation in widespread brain regions, including the anterior cingulate cortex (ACC), motor cortex, endopiriform nucleus, bed nuclei of the stria terminalis, and dentate gyrus. Neurons in the ACC, motor cortex, and dentate gyrus exhibit distinct alterations in excitatory synaptic transmission and intrinsic neuronal excitability. These results suggest that NGL-1 is important for normal locomotor activity, anxiety-like behavior, and learning and memory, as well as synapse properties and excitability of neurons in widespread brain regions under baseline and anxiety-inducing conditions.</p>