10.3389/fnhum.2019.00327.s001
Victoria Zakopoulou
Victoria
Zakopoulou
Angeliki-Maria Vlaikou
Angeliki-Maria
Vlaikou
Marousa Darsinou
Marousa
Darsinou
Zoe Papadopoulou
Zoe
Papadopoulou
Daniela Theodoridou
Daniela
Theodoridou
Kyriaki Papageorgiou
Kyriaki
Papageorgiou
George A. Alexiou
George A.
Alexiou
Haralambos Bougias
Haralambos
Bougias
Vassiliki Siafaka
Vassiliki
Siafaka
Pierluigi Zoccolotti
Pierluigi
Zoccolotti
George P. Chroussos
George P.
Chroussos
Maria Syrrou
Maria
Syrrou
Theologos M. Michaelidis
Theologos M.
Michaelidis
Data_Sheet_1_Linking Early Life Hypothalamic–Pituitary–Adrenal Axis Functioning, Brain Asymmetries, and Personality Traits in Dyslexia: An Informative Case Study.pdf
Frontiers
2019
dyslexia
brain asymmetries
stress
hypothalamic–pituitary–adrenal (HPA) axis
neuroplasticity genes
BDNF
MR
2019-10-01 04:19:30
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Linking_Early_Life_Hypothalamic_Pituitary_Adrenal_Axis_Functioning_Brain_Asymmetries_and_Personality_Traits_in_Dyslexia_An_Informative_Case_Study_pdf/9922916
<p>Developmental dyslexia (DD) is a multi-system disorder, combining influences of susceptibility genes and environmental factors. The causative interaction between specific genetic factors, brain regions, and personality/mental disorders, as well as specific learning disabilities, has been thoroughly investigated with regard to the approach of developing a multifaceted diagnostic procedure with an intervention strategy potential. In an attempt to add new translational evidence to the interconnection of the above factors in the occurrence of DD, we performed a combinatorial analysis of brain asymmetries, personality traits, cognitive and learning skills, and expression profiles of selected genes in an adult, early diagnosed with DD, and in his son of typical development. We focused on the expression of genes, based on the assumption that the regulation of transcription may be affected by genetic and epigenetic factors. The results highlighted a potential chain link between neuroplasticity-related as well as stress-related genes, such as BDNF, Sox4, mineralocorticoid receptor (MR), and GILZ, leftward asymmetries in the amygdala and selective cerebellum lobules, and tendencies for personality disorders and dyslexia. This correlation may reflect the presence of a specific neuro-epigenetic component of DD, ensuing from the continuous, multifaceted difficulties in the acquisition of cognitive and learning skills, which in turn may act as a fostering mechanism for the onset of long-term disorders. This is in line with recent findings demonstrating a dysfunction in processes supported by rapid neural adaptation in children and adults with dyslexia. Accordingly, the co-evaluation of all the above parameters may indicate a stress-related dyslexia endophenotype that should be carefully considered for a more integrated diagnosis and effective intervention.</p>