10.3389/fnins.2019.00833.s001
Zoe Papadopoulou
Zoe
Papadopoulou
Angeliki-Maria Vlaikou
Angeliki-Maria
Vlaikou
Daniela Theodoridou
Daniela
Theodoridou
Chrysoula Komini
Chrysoula
Komini
Georgia Chalkiadaki
Georgia
Chalkiadaki
Marina Vafeiadi
Marina
Vafeiadi
Katerina Margetaki
Katerina
Margetaki
Theoni Trangas
Theoni
Trangas
Chris W. Turck
Chris W.
Turck
Maria Syrrou
Maria
Syrrou
Leda Chatzi
Leda
Chatzi
Michaela D. Filiou
Michaela D.
Filiou
Image_1_Unraveling the Serum Metabolomic Profile of Post-partum Depression.pdf
Frontiers
2019
PPD
early life stress
pregnancy
psychiatric disorders
metabolomics
biomarkers
serum
2019-08-23 12:34:15
Figure
https://frontiersin.figshare.com/articles/figure/Image_1_Unraveling_the_Serum_Metabolomic_Profile_of_Post-partum_Depression_pdf/9725096
<p>Post-partum depression (PPD) is a severe psychiatric disorder affecting ∼15% of young mothers. Early life stressful conditions in periconceptual, fetal and early infant periods or exposure to maternal psychiatric disorders, have been linked to adverse childhood outcomes interfering with physiological, cognitive and emotional development. The molecular mechanisms of PPD are not yet fully understood. Unraveling the molecular underpinnings of PPD will allow timely detection and establishment of effective therapeutic approaches. To investigate the underlying molecular correlates of PPD in peripheral material, we compared the serum metabolomes of an in detail characterized group of mothers suffering from PPD and a control group of mothers, all from Heraklion, Crete in Greece. Serum samples were analyzed by a mass spectrometry platform for targeted metabolomics, based on selected reaction monitoring (SRM), which measures the levels of up to 300 metabolites. In the PPD group, we observed increased levels of glutathione-disulfide, adenylosuccinate, and ATP, which associate with oxidative stress, nucleotide biosynthesis and energy production pathways. We also followed up the metabolomic findings in a validation cohort of PPD mothers and controls. To the very best of our knowledge, this is the first metabolomic serum analysis in PPD. Our data show that molecular changes related to PPD are detectable in peripheral material, thus paving the way for additional studies in order to shed light on the molecular correlates of PPD.</p>