10.3389/fnmol.2019.00192.s001 Youngpyo Nam Youngpyo Nam Bitna Joo Bitna Joo Ju-Young Lee Ju-Young Lee Kyung-Min Han Kyung-Min Han Ka-Young Ryu Ka-Young Ryu Young Ho Koh Young Ho Koh Jeongyeon Kim Jeongyeon Kim Ja Wook Koo Ja Wook Koo Young-Man We Young-Man We Hyang-Sook Hoe Hyang-Sook Hoe Data_Sheet_1_ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer’s Disease.docx Frontiers 2019 tau Alzheimer’s disease amyloid plaque long-term memory dendritic spines 2019-08-16 15:01:51 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_ALWPs_Improve_Cognitive_Function_and_Regulate_A_Plaque_and_Tau_Hyperphosphorylation_in_a_Mouse_Model_of_Alzheimer_s_Disease_docx/9638999 <p>Recently, we reported that ALWPs, which we developed by combining Liuwei Dihuang pills (LWPs) with antler, regulate the LPS-induced neuroinflammatory response and rescue LPS-induced short- and long-term memory impairment in wild-type (WT) mice. In the present study, we examined the effects of ALWPs on Alzheimer’s disease (AD) pathology and cognitive function in WT mice as well as 5x FAD mice (a mouse model of AD). We found that administration of ALWPs significantly reduced amyloid plaque levels in 5x FAD mice and significantly decreased amyloid β (Aβ) levels in amyloid precursor protein (APP)-overexpressing H4 cells. In addition, ALWPs administration significantly suppressed tau hyperphosphorylation in 5x FAD mice. Oral administration of ALWPs significantly improved long-term memory in scopolamine (SCO)-injected WT mice and 5x FAD mice by altering dendritic spine density. Importantly, ALWPs promoted spinogenesis in primary hippocampal neurons and WT mice and modulated the dendritic spine number in an extracellular signal-regulated kinase (ERK)-dependent manner. Taken together, our results suggest that ALWPs are a candidate therapeutic drug for AD that can modulate amyloid plaque load, tau phosphorylation, and synaptic/cognitive function.</p>